What question did this study set out to answer?

To determine how prolonged 72-hour angiotensin II infusions influence aldosterone secretion, adrenal hormones, blood pressure, and electrolyte balance in sodium-replete versus sodium-deplete states.

March 1, 1978The Journal of Clinical Endocrinology & Metabolism

Prolonged Infusions of Ile5-Angiotensin-II in Sodium Replete and Deplete Man: Effects on Aldosterone, ACTH, Cortisol, Blood Pressure, and Electrolyte Balance*

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Why the study?

Does prolonged infusion of Angiotensin II affect aldosterone secretion and blood pressure differently in sodium replete versus sodium deplete healthy young men?

Population

12 healthy young men (4 sodium replete, 8 sodium deplete)

Comparison

Angiotensin II infusion for 72 hours vs Appropriate control periods prior to infusion

Design

Other

Follow-up

72 hours

Authors

WOW. OelkersUniversität Ulm MSM. SchöneshöferJüdisches Krankenhaus Berlin GSG. SchultzeNephrologisches Zentrum Villingen-Schwenningen

Discussion

Member takes

Implication

Physiological data in healthy volunteers warrant clinical caution; extends mechanistic understanding of sodium-angiotensin II interactions but requires validation in disease states.

Key Points

To determine how prolonged 72-hour angiotensin II infusions influence aldosterone secretion, adrenal hormones, blood pressure, and electrolyte balance in sodium-replete versus sodium-deplete states.
Infused Ile5-angiotensin II continuously for 72 hours in 4 sodium-replete (3 ng/kg/min) and 8 sodium-deplete (3 or 6 ng/kg/min) healthy young men after control periods.
Assessed plasma and urinary aldosterone, plasma cortisol, ACTH, renin activity, plasma and urinary electrolytes, and blood pressure across both dietary sodium states.
Sodium depletion significantly augmented the absolute increase in aldosterone secretion elicited by angiotensin II infusion compared to the sodium-replete state, confirming zona glomerulosa sensitization.
In sodium-replete subjects, aldosterone levels rose progressively between day 1 and day 2 of infusion, reflecting a trophic effect of angiotensin II on the adrenal cortex.
Blood pressure pressor responses to angiotensin II were blunted by sodium depletion, whereas plasma ACTH, cortisol, and potassium balance remained without significant changes.

Structured PICO

Does prolonged infusion of Angiotensin II affect aldosterone secretion and blood pressure differently in sodium replete versus sodium deplete healthy young men?

Population

12 healthy young men (4 sodium replete, 8 sodium deplete)

Intervention

Angiotensin II (Ile5) infusion for 72 hours (3 ng/kg/min for sodium replete subjects; 3 or 6 ng/kg/min for sodium deplete subjects)

Comparator

Appropriate control periods prior to infusion

Outcome

Aldosterone secretion, plasma cortisol, ACTH, renin activity, plasma and urinary electrolytes, and blood pressuresurrogate

Prolonged angiotensin II infusion demonstrates that sodium deficiency sensitizes the zona glomerulosa to angiotensin II, increasing aldosterone secretion while blunting its pressor effects.

Cite This Study

Oelkers et al. (1978) studied this question.

synapsesocial.com/papers/6a7a96e8a51ded8e7b32cdc8 https://doi.org/10.1210/jcem-46-3-402

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Implication

Physiological data in healthy volunteers warrant clinical caution; extends mechanistic understanding of sodium-angiotensin II interactions but requires validation in disease states.

Prolonged Infusions of Ile5-Angiotensin-II in Sodium Replete and Deplete Man: Effects on Aldosterone, ACTH, Cortisol, Blood Pressure, and Electrolyte Balance*

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Prolonged Infusions of Ile5-Angiotensin-II in Sodium Replete and Deplete Man: Effects on Aldosterone, ACTH, Cortisol, Blood Pressure, and Electrolyte Balance*

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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