What question did this study set out to answer?

To determine whether the physiological and renal effects of angiotensin I in humans are mediated entirely by its conversion to angiotensin II in plasma.

April 1, 1998Cardiovascular ResearchOpen Access

Dissociation between the renal effects of angiotensin I and II in sodium-restricted normal subjects

Q: What does this research mean for the field?

Angiotensin I and Angiotensin II exert similar systemic effects on blood pressure and aldosterone but have distinct renal effects, suggesting a low renal capacity to convert Angiotensin I to Angiotensin II. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Why the study?

Does Angiotensin I have different renal and systemic effects compared to Angiotensin II in healthy male volunteers on a sodium-restricted diet?

Key Points

To determine whether the physiological and renal effects of angiotensin I in humans are mediated entirely by its conversion to angiotensin II in plasma.
Randomized crossover study in 10 healthy male volunteers maintained on a sodium-restricted diet across two separate sessions.
Infused angiotensin I or angiotensin II at escalating doses of 0.3, 1.0, and 3.0 pmol · kg⁻¹ · min⁻¹.
Measured mean arterial pressure (MAP), effective renal plasma flow (ERPF), glomerular filtration rate (GFR), active plasma renin concentration (APRC), aldosterone, and catecholamines during infusion and up to 60 minutes post-infusion.
Plasma angiotensin II concentrations increased significantly less during angiotensin I infusion than during angiotensin II infusion (P < 0.05), despite comparable changes in MAP, aldosterone, and GFR.
Angiotensin II infusion caused significantly greater decrements in APRC and ERPF compared with angiotensin I infusion (P < 0.05).
Hemodynamic variables, aldosterone, and angiotensin II levels returned to baseline within 1 hour post-infusion, while renin remained significantly suppressed (P < 0.05).

Structured PICO

Does Angiotensin I have different renal and systemic effects compared to Angiotensin II in healthy male volunteers on a sodium-restricted diet?

Population

10 healthy male volunteers on a sodium-restricted diet

Intervention

Angiotensin I (AngI) infused in increasing doses of 0.3, 1 and 3 pmol x kg-1 x min-1

Comparator

Angiotensin II (AngII) infused in increasing doses of 0.3, 1 and 3 pmol x kg-1 x min-1

Outcome

Changes in mean arterial pressure (MAP), effective renal plasma flow (ERPF), glomerular filtration rate (GFR), active plasma renin concentration (APRC), AngII, aldosterone (Aldo) and catecholaminessurrogate

Angiotensin I and II exert similar systemic blood pressure and aldosterone effects but differ in their renal effects, suggesting a low renal capacity to convert AngI to AngII.

Discussion

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Implication

Comparable systemic/aldosterone effects mask greater renal vasoconstriction with AngII; challenges full plasmatic conversion assumption and extends intrarenal RAAS models.

Cite This Study

Mariëlle Krekels (1998) studied this question.

synapsesocial.com/papers/6a1a1cf6443d3ecd7cdf5cef https://doi.org/10.1016/s0008-6363(97)00288-5

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Implication

Comparable systemic/aldosterone effects mask greater renal vasoconstriction with AngII; challenges full plasmatic conversion assumption and extends intrarenal RAAS models.

Dissociation between the renal effects of angiotensin I and II in sodium-restricted normal subjects

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Dissociation between the renal effects of angiotensin I and II in sodium-restricted normal subjects

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider