Why the study?
Does sodium depletion alter the pressor and steroidogenic actions of angiotensin peptides in conscious rats?
Population
normal and sodium-depleted, conscious rats
Comparison
seven angiotensin agonists and antagonists vs normal rats (control responses)
Design
Preclinical
Authors
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Sodium depletion attenuates pressor responses in rats while preserving steroidogenesis; leaves open translation to human sodium-angiotensin physiology.
Does sodium depletion alter the pressor and steroidogenic actions of angiotensin peptides in conscious rats?
Angiotensin II regulates steroidogenesis independently of conversion to angiotensin III in normal sodium states, but sodium depletion increases the steroidogenic contribution of angiotensin III.
Campbell et al. (1979) studied this question.
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