Why the study?
Does Sar1-Ile8-angiotensin II affect blood pressure, plasma aldosterone, and plasma renin activity differently than angiotensin II in normal anaesthetized dexamethasone suppressed dogs?
Population
Normal anaesthetized dexamethasone suppressed dogs
Comparison
Infusions of the angiotensin analogue… vs Infusions of equimolar doses of angiotensin II
Design
Preclinical
Follow-up
40 min after infusions
Authors
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Suggests selective agonism at adrenal/renal receptors in dogs; leaves open translation to human cardiovascular therapy.
Does Sar1-Ile8-angiotensin II affect blood pressure, plasma aldosterone, and plasma renin activity differently than angiotensin II in normal anaesthetized dexamethasone suppressed dogs?
Sar1-Ile8-angiotensin II acts as a strong agonist at adrenal and renal angiotensin receptors but is almost ineffective at vascular receptors in dogs.
Beckerhoff et al. (1974) studied this question.
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