Why the study?
Does Sar1-angiotensin II have different effects on blood pressure and aldosterone stimulation compared to Asp1-angiotensin II in dogs?
Population
Adrenocorticotrophic hormone-suppressed, bilaterally nephrectomized male mongrel dogs (n = 12)
Comparison
Infusion with Sar1-angiotensin II and… vs Comparison between Sar1-angiotensin II and…
Design
Preclinical
Authors
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Suggests angiotensin II receptor heterogeneity between canine vasculature and adrenal cortex; hypothesis-generating with uncertain human relevance.
Does Sar1-angiotensin II have different effects on blood pressure and aldosterone stimulation compared to Asp1-angiotensin II in dogs?
The differential effects of angiotensin II analogs on blood pressure and aldosterone suggest functional differences in angiotensin II receptors between vascular smooth muscle and the adrenal cortex.
Bravo et al. (1976) studied this question.
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