April 1, 1976Endocrinology
Actions of Angiotensin II Antagonists upon Aldosterone Production by Isolated Adrenal Glomerulosa Cells
Population
Isolated canine glomerulosa cell preparation (dog adrenal cells)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Animal data on angiotensin II analogues should not alter practice; leaves open refinement of pure antagonists for aldosterone suppression.
Structured PICO
P
Population
Isolated canine glomerulosa cell preparation (dog adrenal cells)
I
Intervention
Angiotensin II antagonists (including [Sar1, Ile8], [Sar1, Ala8], [Sar1, Gly8], and [Des-Asp1, Ile8] derivatives of angiotensin II)
O
Outcome
Aldosterone production (basal and angiotensin II-stimulated)surrogate
In isolated canine adrenal cells, octapeptide angiotensin II antagonists are more effective than heptapeptide antagonists, and increased aliphatic side chain length at the C-terminus enhances receptor affinity but also increases agonist activity on aldosterone synthesis.
Cite This Study
Saltman et al. (1976) studied this question.