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August 1, 1975Endocrinology

Competitive Binding Activity of Angiotensin II Analogues in an Adrenal Cortex Radioligand-Receptor Assay

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Population

Bovine adrenal cortex homogenate and [125I] iodoangiotensin II (in vitro model)

Comparison

Angiotensin II analogues vs Native angiotensin II

Design

Preclinical

Authors

SSS. SaltmanWashington University in St. LouisABAlbert J. BaukalNational Institutes of HealthSWSamuel T. WatersBeth Israel Deaconess Medical Center

Discussion

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Implication

Adrenal assay data on angiotensin II analogues may guide analogue design; leaves open in vivo efficacy and clinical translation.

Structured PICO

P
Population
Bovine adrenal cortex homogenate and [125I] iodoangiotensin II (in vitro model)
I
Intervention
Angiotensin II analogues (agonists and antagonists)
C
Comparator
Native angiotensin II
O
Outcome
Competitive binding-inhibition activitysurrogate

The adrenal radioligand receptor assay provides a valid method for analyzing the binding affinity of angiotensin II analogues, demonstrating that binding-inhibition potency correlates with biological activity and is influenced by N-terminal basicity.

Cite This Study

Saltman et al. (1975) studied this question.

synapsesocial.com/papers/6a8a3e60b1e5d05ea8ec970ehttps://doi.org/10.1210/endo-97-2-275
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative Studies of Receptor Binding and Steroidogenic Properties of Angiotensins in the Rat Adrenal Glomerulosa*1979 · 17 citations
  2. 2Actions of Angiotensin II Antagonists upon Aldosterone Production by Isolated Adrenal Glomerulosa Cells1976 · 27 citations
  3. 3Inhibition of Induced Aldosterone Biosynthesis with a Specific Antagonist of Angiotensin II1974 · 45 citations
  4. 4Role of the N-terminal Amino Acid for the Biological Activities of Angiotensin and Inhibitory Analogues1974 · 42 citations
  5. 5Binding Characteristics and Vascular Effects of Various Angiotensin II Antagonists1990 · 60 citations