January 1, 1990Journal of Cardiovascular Pharmacology

Binding Characteristics and Vascular Effects of Various Angiotensin II Antagonists

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Population

Rat aortic smooth muscle cells, human uterus, and isolated rabbit aortic rings

Design

Preclinical

Authors

LCLeoluca CriscioneNovartis (Switzerland)HTH ThomannNovartis (Switzerland)SWSteven WhitebreadNovartis (United States)

Discussion

Member takes

Implication

Hypothesis-generating for Ang IIB-selective antagonists in hypertension; human translation untested.

Structured PICO

Population

Rat aortic smooth muscle cells (Ang IIB subtype), human uterus (Ang IIA subtype), and isolated rabbit aortic rings

Intervention

Various Angiotensin II receptor ligands (saralasin, [Sar1 Ile8]-Ang II, CGP 42112A, compound 89, Ex 169)

Outcome

Binding affinity (Ki) and inhibition of Ang II-induced contractions (IC50)surrogate

The Ang IIB receptor subtype mediates vascular contractions, indicating that antagonists targeting this specific receptor subtype have potential as antihypertensive agents.

Cite This Study

Criscione et al. (1990) studied this question.

synapsesocial.com/papers/6a82bb2fdb35670cc923b77a https://doi.org/10.1097/00005344-199016004-00012

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January 1, 1990Journal of Cardiovascular Pharmacology

Binding Characteristics and Vascular Effects of Various Angiotensin II Antagonists

View Full Paper

Ask AI

Bookmark

Population

Rat aortic smooth muscle cells, human uterus, and isolated rabbit aortic rings

Design

Preclinical

Authors

LCLeoluca CriscioneNovartis (Switzerland)HTH ThomannNovartis (Switzerland)SWSteven WhitebreadNovartis (United States)

Discussion

Member takes

Implication

Hypothesis-generating for Ang IIB-selective antagonists in hypertension; human translation untested.

Structured PICO

Population

Rat aortic smooth muscle cells (Ang IIB subtype), human uterus (Ang IIA subtype), and isolated rabbit aortic rings

Intervention

Various Angiotensin II receptor ligands (saralasin, [Sar1 Ile8]-Ang II, CGP 42112A, compound 89, Ex 169)

Outcome

Binding affinity (Ki) and inhibition of Ang II-induced contractions (IC50)surrogate

The Ang IIB receptor subtype mediates vascular contractions, indicating that antagonists targeting this specific receptor subtype have potential as antihypertensive agents.

Cite This Study

Criscione et al. (1990) studied this question.

synapsesocial.com/papers/6a82bb2fdb35670cc923b77a https://doi.org/10.1097/00005344-199016004-00012

Also Consider

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