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July 1, 1988AJP Endocrinology and Metabolism

Angiotensin II receptors in rabbit renal preglomerular vessels

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Population

Rabbit renal preglomerular vessels from pregnant and nonpregnant rabbits

Design

Preclinical

Authors

GBG. P. BrownUniversity at Buffalo, State University of New YorkRVRocco C. VenutoErie County Medical Center

Discussion

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Implication

No pregnancy-related shift in rabbit renal ANG II receptor binding; leaves open translational relevance to human gestational vascular physiology.

Structured PICO

P
Population
Rabbit renal preglomerular vessels (arcuate and interlobular arteries, with attached proximal segments of afferent arterioles) from pregnant and nonpregnant rabbits
I
Intervention
125I-ANG II radioreceptor assay and binding inhibition with ANG analogues
O
Outcome
Binding site concentrations [N] and dissociation constants [KD]surrogate

Demonstrates the presence of a single class of high-affinity angiotensin II receptors in rabbit renal preglomerular vessels with specific binding affinities for various ANG analogues.

Cite This Study

Brown et al. (1988) studied this question.

synapsesocial.com/papers/6a87f1e0fa9d1f0cc658268chttps://doi.org/10.1152/ajpendo.1988.255.1.e16
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin antagonists with increased specificity for the renal vasculature.1977 · 37 citations
  2. 2Interaction between renal prostaglandins and angiotensin II in controlling glomerular filtration in the dog1987 · 24 citations
  3. 3Properties of Angiotensin II Receptors of Isolated Rat Glomeruli: Factors Influencing Binding Affinity and Comparative Binding of Angiotensin Analogs*1980 · 50 citations
  4. 4Regulation of vascular angiotensin II receptors in the rat during altered sodium intake.1981 · 127 citations
  5. 5Receptor binding of angiotensin II and antagonists. Correlation with aldosterone production by isolated canine adrenal glomerulosa cells.1976 · 39 citations