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July 1, 1986AJP Endocrinology and Metabolism

Angiotensin II receptor alterations during pregnancy in rabbits

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Population

24- to 28-day pregnant rabbits and nonpregnant rabbits

Comparison

Pregnancy vs Nonpregnant rabbits

Design

Preclinical

Authors

GBG. P. BrownUniversity at Buffalo, State University of New YorkRVRocco C. VenutoErie County Medical Center

Discussion

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Overview

Ang II receptor downregulation may mediate gestational vascular refractoriness in rabbits; leaves open applicability to human pregnancy.

Structured PICO

P
Population
24- to 28-day pregnant rabbits and nonpregnant rabbits
I
Intervention
Pregnancy (and meclofenamate administration in a subset of pregnant rabbits)
C
Comparator
Nonpregnant rabbits
O
Outcome
Angiotensin II binding site concentrations (N) and dissociation constants (Kd) in vascular (glomeruli and mesenteric arteries) and nonvascular (adrenal glomerulosa) tissuessurrogate

Pregnancy in rabbits leads to a downregulation of Angiotensin II receptors in vascular tissues, which may contribute to the decreased pressor response to Ang II during pregnancy.

Cite This Study

Brown et al. (1986) studied this question.

synapsesocial.com/papers/6a86e70046ba7ceb229ead71https://doi.org/10.1152/ajpendo.1986.251.1.e58
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Plasma Renin Activity and Adrenal Angiotensin II Receptors in Fetal, Newborn, Adult and Pregnant Rabbits2009 · 18 citations
  2. 2Prostglandis, angiotensin and blood pressure in pregnant rabbits1983 · 2 citations
  3. 3Pressor responses to norepinephrine during captopril in renal prehypertensive rabbits.1983 · 19 citations
  4. 4Reciprocal Influence of Salt Intake on Adrenal Glomerulosa and Renal Vascular Responses to Angiotensin II in Normal Man1974 · 333 citations
  5. 5Properties of Angiotensin II Receptors of Isolated Rat Glomeruli: Factors Influencing Binding Affinity and Comparative Binding of Angiotensin Analogs*1980 · 50 citations