Key result
Angiotensin-II injection directly into the uterine blood supply dose-dependently increased uterine vascular resistance in both pregnant and nonpregnant rabbits.
Why the study?
Does angiotensin-II increase uterine vascular resistance in pregnant and nonpregnant rabbits?
Population
Pregnant and nonpregnant rabbits anesthetized with pentobarbital
Comparison
Graded doses of angiotensin-II injected directly… vs Responses in the presence of…
Design
Preclinical
Authors
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Supports direct angiotensin-II vasoconstriction in rabbit uterine vessels; leaves open translation to human pregnancy and preeclampsia.
Does angiotensin-II increase uterine vascular resistance in pregnant and nonpregnant rabbits?
Angiotensin-II directly induces active uterine vasoconstriction independent of alpha-adrenergic mechanisms in both pregnant and nonpregnant rabbits.
Cohen et al. (1977) studied Pregnant and nonpregnant rabbits. Angiotensin-II (A-II) injection was evaluated on Uterine vascular resistance. Angiotensin-II injection directly into the uterine blood supply dose-dependently increased uterine vascular resistance in both pregnant and nonpregnant rabbits.
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