Why the study?
Does angiotensin II mediate uterine vasoconstriction through alpha-stimulation in pregnant and nonpregnant ewes?
Does angiotensin II mediate uterine vasoconstriction through alpha-stimulation in pregnant and nonpregnant ewes?
Angiotensin II increases uterine vascular resistance indirectly via AT1 receptor-mediated release of an alpha-agonist rather than direct action on uterine vascular smooth muscle.
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Caution against clinical extrapolation in pregnancy; extends ovine models of indirect AT1-alpha vasoconstriction.
Cox et al. (2004) studied this question.
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