Population
7 nonpregnant estrogenized ewes with indwelling uterine artery catheters and flow probes
Comparison
Angiotensin II local bolus injections and… vs Baseline responses to ANG II prior to receptor…
Design
Preclinical
Authors
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Highlights AT1/AT2 balance in ovine uterine flow; leaves open translation to human pregnancy or RAS therapies.
In nonpregnant ewes, AT1 receptors mediate systemic and uterine vasoconstriction to ANG II, while AT2 receptors modulate and potentially buffer this response via nitric oxide release.
Lambers et al. (2000) studied this question.
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