December 1, 1998British Journal of PharmacologyOpen Access

Modulation of AT₁ receptor‐mediated contraction of rat uterine artery by AT₂ receptors

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Population

Isolated uterine arteries from virgin, non-pregnant and late pregnant (18-21 days) Sprague-Dawley rats

Comparison

Angiotensin II in the presence of AT1… vs Angiotensin II in the absence of receptor…

Design

Preclinical

Authors

AZAdam S ZwartCentre for Human Drug Research EDElizabeth A. DavisThe Kids Research Institute Australia RWRobert E. WiddopGeneral Cardiology

Discussion

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Implication

May guide AT receptor studies in pregnancy models; leaves open translation to human uterine vasculature.

Structured PICO

Population

Isolated uterine arteries from virgin, non-pregnant and late pregnant (18-21 days) Sprague-Dawley rats

Intervention

Angiotensin II (1 nM-10 microM) in the presence of AT1 antagonist (losartan), AT2 antagonist (PD 123319), or AT2 agonist (CGP 42112)

Comparator

Angiotensin II in the absence of receptor subtype selective compounds

Outcome

Contractile responses measured as increases in force (mN) and expressed as a per cent of the response to a K+ depolarizing solutionsurrogate

Contractile responses of the rat uterine artery to angiotensin II are mediated by the AT1 receptor, while the AT2 receptor appears to inhibit this AT1-mediated response.

Cite This Study

Zwart et al. (1998) studied this question.

synapsesocial.com/papers/6a74ab718d2049c8dd03336e https://doi.org/10.1038/sj.bjp.0702210

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Modulation of AT₁ receptor‐mediated contraction of rat uterine artery by AT₂ receptors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Modulation of AT₁ receptor‐mediated contraction of rat uterine artery by AT₂ receptors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider