Key result
Angiotensin II responses were greater during pregnancy, with an increased contraction in response to AT2 receptor blockade at mid-gestation, suggesting AT2 modulates Ang-II contractile responses.
Population
C57BL/6J mice divided into three groups: non-pregnant, mid-gestation, and late-gestation
Comparison
Angiotensin II exposure with AT1 or AT2 receptor… vs Non-pregnant mice and different gestation stages
Design
Preclinical
Authors
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AT2 modulation of Ang-II responses may influence gestational vascular adaptations; leaves open clinical relevance in human pregnancy disorders.
In a mouse model, AT2 receptor-mediated vasodilatation appears to modulate Ang-II contractile responses in the uterine artery during pregnancy.
Pulgar et al. (2011) studied Pregnancy. Pregnancy (mid and late gestation) vs. Non-pregnant state was evaluated on Uterine artery reactivity (diameter, KCl-mediated responses, acetylcholine-dependent vasorelaxation, Ang-II responses). Angiotensin II responses were greater during pregnancy, with an increased contraction in response to AT2 receptor blockade at mid-gestation, suggesting AT2 modulates Ang-II contractile responses.
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