Key result
Pregnancy was associated with a more than 8-fold increase in AT1-R expression in the uterine artery endothelium of ewes compared to nonpregnant ewes (P<0.05).
Population
Pregnant ewes at 110, 120, 130, and 142 days of gestation (n=16) and nonpregnant ewes (n=6).
Comparison
Pregnancy (gestational state) vs Nonpregnant state
Design
Preclinical
Authors
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May inform mechanisms of gestational uterine vasodilation in ewes; hypothesis-generating with unclear human relevance.
Effect estimate: 8-fold increase
p-value: p=<0.05
Pregnancy induces a marked and localized increase in AT1-R expression in uterine artery endothelium, providing a molecular mechanism for increased uterine blood flow during pregnancy.
Ian M. Bird (1997) studied Pregnancy. Pregnancy vs. Nonpregnant state was evaluated on AT1-R expression in uterine artery endothelium (8-fold increase, p=<0.05). Pregnancy was associated with a more than 8-fold increase in AT1-R expression in the uterine artery endothelium of ewes compared to nonpregnant ewes (P<0.05).
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