Why the study?
Does pregnancy increase AT1-R expression in uterine artery endothelium in ewes?
Population
Pregnant ewes at 110, 120, 130, and 142 days of gestation and nonpregnant ewes for Western analysis…
Comparison
Pregnancy (gestational state) vs Nonpregnant state
Design
Preclinical
Authors
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May support AT1-R role in ovine gestational uterine perfusion; leaves open human translational relevance.
Does pregnancy increase AT1-R expression in uterine artery endothelium in ewes?
Pregnancy induces a marked, localized increase in AT1-R expression in uterine artery endothelium, which may explain the increased prostacyclin responsiveness and uterine blood flow necessary for fetal development.
Bird et al. (1997) studied this question.
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