Why the study?
Does systemic versus local Angiotensin II infusion alter uterine vascular resistance and blood flow in pregnant and nonpregnant ewes?
Population
11 sheep (6 near-term pregnant and 5 ovariectomized nonpregnant ewes)
Comparison
Systemic Angiotensin II (ANG II) infusions vs Local intra-arterial Angiotensin II infusions
Design
Preclinical
Authors
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Indicates indirect systemic ANG II effects on uterine vasculature in ewes; hypothesis-generating for pregnancy-attenuated responses pending human studies.
Does systemic versus local Angiotensin II infusion alter uterine vascular resistance and blood flow in pregnant and nonpregnant ewes?
Systemic Angiotensin II increases uterine vascular resistance indirectly, likely through the release of other vasoconstrictors, with attenuated responses during pregnancy.
Cox et al. (2000) studied this question.
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