Why the study?
Does angiotensin II increase prostacyclin production in ovine uterine and systemic arteries during pregnancy?
Does angiotensin II increase prostacyclin production in ovine uterine and systemic arteries during pregnancy?
The reduced systemic pressor response to angiotensin II during pregnancy may be mediated by increased vessel production of prostacyclin, particularly in the uterine vasculature where ANG II specifically stimulates its synthesis.
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May mediate blunted ANG II pressor responses in ovine pregnancy; leaves open human translation and therapeutic relevance.
Magness et al. (1985) studied this question.
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