Key result
Pregnancy in rabbits was associated with a significantly greater pressor response to angiotensin and noradrenaline, an effect reversed after autonomic ganglion blockade.
Why the study?
Does pregnancy in rabbits alter the pressor response to angiotensin II and noradrenaline?
Population
Near-term pregnant and matched non-pregnant rabbits
Comparison
Angiotensin II and noradrenaline, with and… vs Matched non-pregnant rabbits
Design
Preclinical
Authors
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Should not change human pregnancy management; hypothesis-generating for autonomic modulation of gestational pressor responses.
Does pregnancy in rabbits alter the pressor response to angiotensin II and noradrenaline?
Pregnancy alters the pressor response to angiotensin and noradrenaline in rabbits, an effect heavily modulated by baseline arterial pressure and baroreceptor reflexes.
Joels et al. (1985) studied Pregnancy. Pregnancy vs. Non-pregnant rabbits was evaluated on Pressor response to angiotensin II and noradrenaline. Pregnancy in rabbits was associated with a significantly greater pressor response to angiotensin and noradrenaline, an effect reversed after autonomic ganglion blockade.
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