Why the study?
Does pregnancy alter the pressor and heart rate responses to intravenous angiotensin II and noradrenaline compared to non-pregnant women?
Population
56 women (28 healthy non-pregnant women and 28 women in the first or second trimester of pregnancy)
Comparison
Incremental intravenous infusion of either… vs Non-pregnant women
Authors
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Supports selective angiotensin II hyporesponsiveness in pregnancy; hypothesis-generating for mechanisms of gestational vascular adaptation.
Does pregnancy alter the pressor and heart rate responses to intravenous angiotensin II and noradrenaline compared to non-pregnant women?
Pregnancy induces a specific pressor insensitivity to angiotensin II rather than a generalized reduction in vascular reactivity.
Ramsay et al. (1992) studied this question.
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