Why the study?
Does prostaglandin E1 infusion alter the pressor response to angiotensin II in pregnant and non-pregnant subjects?
Population
8 pregnant (second trimester) and 6 non-pregnant subjects
Comparison
Simultaneous infusion of prostaglandin E1 during… vs Angiotensin II infusion alone
Design
Other
Authors
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Hypothesis-generating for vascular reactivity in pregnancy; should not change practice without larger controlled studies.
Does prostaglandin E1 infusion alter the pressor response to angiotensin II in pregnant and non-pregnant subjects?
Prostaglandin E1 blunts the pressor response to angiotensin II, particularly in pregnant women who exhibit the greatest initial pressor responses.
Pipkin et al. (1982) studied this question.
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