Population
Pseudopregnant, pregnant, and nonpregnant rats
Comparison
Administration of vasoconstrictors and… vs Nonpregnant rats and baseline responses without…
Design
Preclinical
Follow-up
12 days
Authors
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May implicate prostaglandins in maternal ANG II hyporesponsiveness; leaves open fetal-placental roles and human translation.
Maternal factors alone (pseudopregnancy) are sufficient to decrease pressor responsiveness to angiotensin II and increase urinary PGE excretion, but fetal-placental factors are required for reduced responsiveness to norepinephrine and AVP.
Paller et al. (1989) studied this question.
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