December 1, 1989AJP Regulatory Integrative and Comparative Physiology

Role for central angiotensin II in control of blood pressure during pregnancy

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Population

Conscious pregnant rats

Comparison

Intracerebroventricular angiotensin II and… vs Non-pregnant rats

Design

Preclinical

Authors

THTina HinesAgricultural Research Service JPJames P. PorterBrigham Young University

Discussion

Member takes

Implication

Enhanced central ANG II pressor effects in pregnant animals; leaves open a role for brain RAS in human gestational hypertension.

Structured PICO

Population

Conscious pregnant rats

Intervention

Intracerebroventricular angiotensin II (100 ng) and intravenous angiotensin II, norepinephrine, and vasopressin

Comparator

Non-pregnant rats (implied by comparison of responses in pregnancy)

Outcome

Pressor response (blood pressure change)surrogate

Central effects of angiotensin II are augmented during pregnancy, suggesting a significant role for central ANG II in blood pressure regulation in this state.

Cite This Study

Hines et al. (1989) studied this question.

synapsesocial.com/papers/6a6f6f6dce524a4339c35ecb https://doi.org/10.1152/ajpregu.1989.257.6.r1457

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Role for central angiotensin II in control of blood pressure during pregnancy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Role for central angiotensin II in control of blood pressure during pregnancy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider