March 12, 2004AJP Heart and Circulatory Physiology

Central angiotensin II-induced pressor responses and neural activity in utero and hypothalamic angiotensin receptors in preterm ovine fetus

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Population

Chronically prepared preterm ovine fetus

Design

Preclinical

Authors

ZXZhice XuSouthwest University LSLijun ShiHarbin Medical University JYJiaming YaoBengbu Medical College

Discussion

Member takes

Implication

Should not yet inform preterm fetal management; leaves open whether central ANG II pathways mature similarly in human neonates.

Structured PICO

Population

Chronically prepared preterm ovine fetus

Intervention

Central application (intracerebroventricular injection) of angiotensin II (ANG II)

Outcome

Fetal blood pressure (mean arterial pressure), heart rate, c-Fos expression in fetal central pathways, and angiotensin subtype 1 receptors in the fetal hypothalamussurrogate

Central angiotensin II-related pressor centers start to function as early as preterm, suggesting the central angiotensin-related sympathetic pathway is intact in utero.

Cite This Study

Xu et al. (2004) studied this question.

synapsesocial.com/papers/6a816ba7adfa6baaaee1d4c9 https://doi.org/10.1152/ajpheart.00764.2003

View Full Paper

Ask AI

Bookmark

Central angiotensin II-induced pressor responses and neural activity in utero and hypothalamic angiotensin receptors in preterm ovine fetus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Central angiotensin II-induced pressor responses and neural activity in utero and hypothalamic angiotensin receptors in preterm ovine fetus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider