Why the study?
How do pregnancy, prostacyclin, and labetalol influence the vascular response to angiotensin II in rats?
How do pregnancy, prostacyclin, and labetalol influence the vascular response to angiotensin II in rats?
This preclinical model supports the hypothesis that vascular refractoriness to angiotensin II during pregnancy is partly mediated by vasodilator prostaglandins such as prostacyclin.
Answers are grounded in this paper and cite their sources.
Should not change clinical hypertension management in pregnancy; leaves open prostacyclin’s mechanistic role in angiotensin II refractoriness for human studies.
AbstractThe mean arterial blood pressure and the vascular response to angiotensin II were studied in chronically catheterized and unanesthetized rats.Pregnancy significantly decreased the pressor response. This effect could be mimicked by prostacyclin infusions in non pregnant rats, whereas labetalol had an opposite effect.The model seems suitable for investigations into the control of vascular reactivity, and reinforces the hypothesis that the relative vascular refractoriness to angiotensin II during pregnancy could result, at least in part, from the action of vasodilator prostaglandins, in this instance prostacyclin
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Spitz et al. (1985) studied this question.
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