Key result
Unmedicated pregnant rabbit model mimics human pregnancy in vascular response to angiotensin II and norepinephrine.
Why the study?
Is the rabbit a suitable model for investigating alterations of vascular response during pregnancy?
Is the rabbit a suitable model for investigating alterations of vascular response during pregnancy?
The chronically catheterized and unmedicated rabbit is a suitable preclinical model for investigating alterations in vascular responsiveness during pregnancy.
Authors
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Supports rabbit model for pregnancy vascular studies; leaves open translation to human therapeutics pending validation.
Lee et al. (1982) studied Pregnancy (n=35). Pregnancy vs. Non-pregnant rabbits was evaluated on Mean arterial pressure, vascular response to angiotensin II and norepinephrine, and plasma hormone levels. The chronically catheterized and unmedicated rabbit model demonstrated striking similarities to human pregnancy regarding vascular responsiveness to angiotensin II and norepinephrine.
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