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Plasma renin activity and adrenal angiotensin II receptors increase rapidly during late gestation in rabbits.
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Rabbit data do not guide neonatal or maternal RAS care; leaves open translational relevance of perinatal angiotensin dynamics.
Plasma renin activity (PRA) and adrenal angiotensin II receptors have been studied simultaneously in the rabbit at various stages of development. In the fetus both parameters show very low values but increase rapidly during the last 4 days of gestation. PRA reaches a maximal level in the early post-natal period but the concentration of adrenal angiotensin II receptors continues to increase further up to the adult state. In adult females, pregnancy results in an initial rise in PRA and adrenocortical angiotensin II receptors. However, PRA remains at a high level throughout the gestation period whereas the number of adrenocortical angiotensin II receptors decreases progressively as pregnancy progresses. The role of circulating angiotensin in the regulation of the concentration and affinity of its receptor sites is discussed.
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Pernollet et al. (2009) studied this question. Developmental stage and pregnancy was evaluated on Plasma renin activity and adrenal angiotensin II receptors. Plasma renin activity and adrenal angiotensin II receptors increase rapidly during late gestation and early post-natal periods, with divergent patterns observed during pregnancy in adult female rabbits.
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