Population
Immature and adult rabbits (bioassay using rat ascending colon)
Comparison
Removal of 25% of calculated blood volume and… vs Adult rabbits; intact versus nephrectomized…
Design
Preclinical
Authors
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May inform neonatal RAS physiology; leaves open translation from rabbit models to human infants.
The renin-angiotensin system shows pronounced activity in immature rabbits, particularly during hemorrhage, suggesting its importance in early-life cardiovascular control.
Pipkin et al. (1971) studied this question.
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