The continuous estimation of angiotensin formed in the circulation of the dog
Why the study?
Does reduction of renal blood pressure or hemorrhage increase circulating angiotensin in dogs?
Population
Dog model (using rat colon as a blood-bathed organ bioassay)
Comparison
Reduction of renal blood pressure or hemorrhage vs Baseline state
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Supports rapid renin response in animal hypotension models; extends physiology but leaves human translation open.
Structured PICO
Does reduction of renal blood pressure or hemorrhage increase circulating angiotensin in dogs?
P
Population
Dog model (using rat colon as a blood-bathed organ bioassay)
I
Intervention
Reduction of renal blood pressure (via partial aortic occlusion) or hemorrhage
C
Comparator
Baseline state
O
Outcome
Changes in circulating angiotensin concentrationsurrogate
Demonstrates that renin secretion by the kidneys in response to a fall in renal blood pressure is a rapid physiological response important for homeostasis.
Cite This Study
Regoli et al. (1966) studied this question.