Why the study?
Does infusion of renin substrate or angiotensin II alter the fractional distribution of renal blood flow in isolated dog kidneys?
Population
Isolated blood-perfused dog kidneys
Comparison
Infusions of tetradecapeptide renin substrate… vs Continued perfusion without infusion
Design
Preclinical
Follow-up
150 minutes
Authors
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May support local angiotensin generation regulating inner cortical flow in canine kidneys; leaves open relevance to human renal physiology.
Does infusion of renin substrate or angiotensin II alter the fractional distribution of renal blood flow in isolated dog kidneys?
The study provides evidence that angiotensin may act as an intrarenal hormone regulating deep cortical and medullary vascular resistance, a function not replicated by circulating angiotensin II.
Itskovitz et al. (1973) studied this question.
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