Relation of renal hemodynamics to metabolism of angiotensin II by the canine kidney.
Population
Pentobarbital-anesthetized dogs
Comparison
Reduction in glomerular filtration rate or… vs Control conditions
Design
Preclinical
Authors
Discussion
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Member takes
Implication
No change to clinical renin-angiotensin management; leaves open flow-dependent angiotensin II metabolism for human validation.
Structured PICO
P
Population
Pentobarbital-anesthetized dogs
I
Intervention
Reduction in glomerular filtration rate (via increased ureteral pressure) or reduction in renal blood flow, with intrarenal injection of 14C- or 125I-labeled angiotensin II
C
Comparator
Control conditions (normal glomerular filtration rate and renal blood flow)
O
Outcome
Percentage of labeled material recovered as angiotensin II versus metabolic products in the renal venous effluentsurrogate
Intrarenal metabolism of angiotensin II in dogs is regulated by alterations in renal blood flow rather than glomerular filtration, occurring mainly in the vascular compartment.
Cite This Study
Bailie et al. (1977) studied this question.