Why the study?
How do the renin-angiotensin system and sympathetic nervous system interact to affect systemic hemodynamics and regional blood flow in conscious dogs with acute renovascular hypertension?
Population
Conscious dogs submitted to renal artery occlusion by inflation of a previously implanted cuff
Comparison
Pretreatment with alpha- and beta-adrenergic… vs Intact dogs undergoing the same renal artery…
Design
Preclinical
Authors
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Hypothesis-generating in conscious dogs; leaves open whether RAS-SNS interactions translate to human renovascular hypertension.
How do the renin-angiotensin system and sympathetic nervous system interact to affect systemic hemodynamics and regional blood flow in conscious dogs with acute renovascular hypertension?
In a canine model of acute renovascular hypertension, both the renin-angiotensin and sympathetic nervous systems contribute to blood pressure elevation, with sympathetic reflexes protecting against angiotensin-induced coronary vasoconstriction.
Gavras et al. (1980) studied this question.
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