Key result
Induction of two-kidney, one clip hypertension in conscious dogs significantly increased blood pressure (107 vs 88 mm Hg, p<0.05) and was associated with early increases in plasma and CSF NE and AIIir.
Population
17 conscious dogs (8 experimental, 9 sham-operated)
Comparison
Two-kidney, one clip hypertension produced by a… vs Sham operation
Design
Preclinical
Follow-up
28 days
Authors
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Supports early neurohormonal activation in renovascular hypertension models; hypothesis-generating and should not yet change practice.
p-value: p=<0.05
The development of renovascular hypertension in a canine model involves early activation of both the sympathetic nervous system and the renin-angiotensin system, as evidenced by changes in plasma and CSF biomarkers.
Suzuki et al. (1983) studied Renal hypertension (n=17). Two-kidney, one clip (2K1C) hypertension induction vs. Sham operation was evaluated on Blood pressure and levels of norepinephrine, epinephrine, and angiotensin II immunoreactivity in plasma and CSF (p=<0.05). Induction of two-kidney, one clip hypertension in conscious dogs significantly increased blood pressure (107 vs 88 mm Hg, p<0.05) and was associated with early increases in plasma and CSF NE and AIIir.
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