Key result
Partial occlusion of the left renal artery significantly increased vascular ACE activity and ANG II production in isolated arteries at 8 months compared to normotensive dogs.
Population
Mongrel dogs with two-kidney, one clip (2-K, 1C) hypertension
Comparison
Partial occlusion of the left renal artery to… vs Normotensive dogs
Design
Preclinical
Follow-up
8 months
Authors
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May implicate local vascular angiotensin II in sustained hypertension; hypothesis-generating for human studies.
Increased vascular ACE activity and local angiotensin II production may maintain chronic hypertension even when systemic plasma renin and ACE activities return to normal.
Miyazaki et al. (1987) studied Two-kidney, one clip (2-K, 1C) hypertension. Partial occlusion of the left renal artery vs. Normotensive dogs was evaluated on Vascular ACE activity and ANG II production. Partial occlusion of the left renal artery significantly increased vascular ACE activity and ANG II production in isolated arteries at 8 months compared to normotensive dogs.
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