Population
Rats with one-kidney, one clip (1K1C) renal hypertension (RHR) and normotensive control rats (total n=96).
Comparison
Development of 1K1C hypertension and reversal… vs Normotensive control rats and sham-operated rats.
Design
Preclinical
Follow-up
Up to 80-120 days after clipping, and 24 hours after…
Authors
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Reversible ACE changes in this rat model support mechanistic research; leaves open any role in human renovascular hypertension.
Chronic 1K1C renal hypertension in rats is associated with elevated plasma ACE activity that reverses upon removal of the renal clip, indicating altered vasoactive peptide metabolism.
Santos et al. (1989) studied this question.
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