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October 1, 1985Journal of Hypertension

Vascular Neuroeffector Function in Two-Kidney, One Clip Hypertensive Dogs

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Population

Dogs (control and made hypertensive for 1 and 8 months by partially occluding a renal artery)

Comparison

Two-kidney, one clip hypertension model vs Control dogs

Design

Preclinical

Follow-up

1 and 8 months

Authors

NTNoboru TodaNational Institute of Advanced Industrial Science and TechnologyMMMizuo MiyazakiOsaka Medical and Pharmaceutical UniversityTOTomio OkamuraShiga University of Medical Science

Discussion

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Implication

These animal findings should not change clinical practice; leaves open whether enhanced vascular ACE and ANG II sensitivity sustain human renovascular hypertension.

Structured PICO

P
Population
Dogs (control and made hypertensive for 1 and 8 months by partially occluding a renal artery)
I
Intervention
Two-kidney, one clip hypertension model (1 and 8 months duration)
C
Comparator
Control dogs
O
Outcome
Contractile responses of mesenteric artery strips to adrenergic nerve stimulation and to norepinephrine, plasma renin activity and vascular angiotensin converting enzyme (ACE) activitysurrogate

In a canine model of renovascular hypertension, chronic hypertension appears to be maintained by increased sensitivity of post-synaptic alpha 1-adrenoceptors, pre-synaptic ANG receptors, and increased vascular ACE activity.

Cite This Study

Toda et al. (1985) studied this question.

synapsesocial.com/papers/6a8bd33d510c7253b5ded5fahttps://doi.org/10.1097/00004872-198510000-00012
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Elevated Vascular Angiotensin Converting Enzyme in Chronic Two-Kidney, One Clip Hypertension in the Dog1987 · 35 citations
  2. 2Neurotransmitter release and vascular responsiveness in mesenteric vasculatures from two-kidney, one-clip goldblatt hypertensive rats.1989 · 4 citations
  3. 3Venous Reactivity in Canine Renovascular Hypertension1990 · 3 citations
  4. 4Vascular responses of the perfused intestine to vasoactive agents during the development of two-kidney, one-clip Goldblatt hypertension in dogs.1981 · 11 citations
  5. 5Hypertension Induced by Chronic Renal Adrenergic Stimulation Is Angiotensin Dependent1995 · 53 citations