Population
Two-kidney, one-clip Goldblatt hypertensive rats (2K, 1C-HT) and sham-operated normotensive control rats
Comparison
Periarterial nerve stimulation and exogenously… vs Sham-operated normotensive control rats
Design
Preclinical
Follow-up
3 weeks and 7-8 weeks after surgery
Authors
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Supports vascular norepinephrine hypersensitivity over sympathetic release in sustaining experimental hypertension; leaves open human translation and targeted therapies.
In two-kidney, one-clip Goldblatt hypertensive rats, increased vascular smooth muscle sensitivity to norepinephrine, rather than increased sympathetic nerve release, contributes to the maintenance of high blood pressure.
Tsuda et al. (1989) studied this question.
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