June 1, 1981Circulation ResearchOpen Access

Vascular responses of the perfused intestine to vasoactive agents during the development of two-kidney, one-clip Goldblatt hypertension in dogs.

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Population

Dogs with two-kidney, one-clip Goldblatt hypertension (2-KGH) or sham occlusion

Comparison

Unilateral renal artery constriction and… vs Sham occlusion of the renal artery and pre-URAC…

Design

Preclinical

Follow-up

32 days

Authors

SGStan S. GreenbergRutgers, The State University of New Jersey

Discussion

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Implication

Suggests vascular hyperreactivity may initiate experimental hypertension; leaves open translation to human renovascular disease.

Structured PICO

Population

Dogs with two-kidney, one-clip Goldblatt hypertension (2-KGH) or sham occlusion

Intervention

Unilateral renal artery constriction (URAC) and administration of vasoactive agents (serotonin, angiotensin II, 9a,11a-epoxymethanoprostaglandin H2, norepinephrine)

Comparator

Sham occlusion of the renal artery (SHAM) and pre-URAC baseline values

Outcome

Changes in segmental vascular resistance in response to vasoactive agentssurrogate

Changes in vascular reactivity precede increased arterial resistance in two-kidney, one-clip Goldblatt hypertension in dogs, occurring first in smaller vessels.

Cite This Study

Stan S. Greenberg (1981) studied this question.

synapsesocial.com/papers/6a8b04af95f0361a9ebeaace https://doi.org/10.1161/01.res.48.6.895

Topics

Hypertension management

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Vascular responses of the perfused intestine to vasoactive agents during the development of two-kidney, one-clip Goldblatt hypertension in dogs.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Vascular responses of the perfused intestine to vasoactive agents during the development of two-kidney, one-clip Goldblatt hypertension in dogs.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

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