Key result
In Goldblatt hypertensive dogs, renal vascular sensitivity to U 46619 increased within 1-2 weeks, while sensitivity to phenylephrine and norepinephrine increased after a month or more.
Population
Conscious Goldblatt hypertensive dogs
Comparison
Intra-arterial infusions of vasoconstrictor and… vs Control sessions
Design
Preclinical
Follow-up
weekly intervals postclipping for a month or more
Authors
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Hypothesis-generating for timed vasoconstrictor roles in renovascular hypertension; leaves open human translation and therapeutic relevance.
In a canine model of Goldblatt hypertension, altered renal vascular reactivity to vasoconstrictor and vasodilator stimuli may contribute to renal hemodynamic changes.
Ben G. Zimmerman (1987) studied Goldblatt hypertension. Intra-arterial infusions of vasoconstrictor and vasodilator agonists (U 46619, adrenergic agonists, angiotensin II) vs. Control sessions (baseline) was evaluated on Renal blood flow (RBF) responses (-% delta RBF). In Goldblatt hypertensive dogs, renal vascular sensitivity to U 46619 increased within 1-2 weeks, while sensitivity to phenylephrine and norepinephrine increased after a month or more.
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