Why the study?
Does intracisternal 6-hydroxydopamine prevent the rise in blood pressure and plasma noradrenaline in a rat model of renovascular hypertension?
Population
Rat model of one-kidney Goldblatt experimental hypertension
Comparison
Pretreatment with intracisternal 6-hydroxydopamine vs Control values (no pretreatment)
Design
Preclinical
Follow-up
Up to 28 days
Authors
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Supports central mediation of sympathetic activation in renovascular hypertension models; leaves open clinical translation.
Does intracisternal 6-hydroxydopamine prevent the rise in blood pressure and plasma noradrenaline in a rat model of renovascular hypertension?
Increased peripheral sympathetic activity in the one-kidney Goldblatt model of experimental hypertension is at least in part centrally mediated.
Dargie et al. (1977) studied this question.
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