May 1, 1982Hypertension
Decrease in hypothalamic norepinephrine content following renal denervation in the one-kidney, one clip Goldblatt hypertensive rat.
Key result
Renal denervation lowers SBP by ~38 mm Hg in hypertensive rats, normalizing hypothalamic norepinephrine.
- P<0.001
Why the study?
Peripheral and central sympathetic mechanisms contribute to hypertension in the one-kidney one clip rat model, but the role of renal nerves in hypothalamic norepinephrine content and blood pressure regulation needed further definition.
Does renal denervation reduce blood pressure and alter central neurotransmitter content in one-kidney, one clip hypertensive rats?
Population
Rats with early established one-kidney one clip hypertension and age-matched uninephrectomized controls
Comparison
Renal denervation vs sham operation
Design
Preclinical experimental study
Follow-up
1 week
Authors
Discussion
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Member takes
Implication
Highlights renal nerves in central sympathetic BP control in rats; leaves open human translation.
Structured PICO
Does renal denervation reduce blood pressure and alter central neurotransmitter content in one-kidney, one clip hypertensive rats?
P
Population
Rats with early established one-kidney one clip hypertension, evaluated 1 week following renal denervation or sham operation.
I
Intervention
Renal denervation performed 2 weeks after renal artery clipping.
C
Comparator
Sham operation.
O
Outcome
Systolic blood pressure and norepinephrine and dopamine content of the hypothalamus, midbrain, pons medulla, and spinal cord at 1 week following intervention.surrogate
Main Result
Absolute Event Rate: 151% vs 189%
p-value: p=<0.001
Renal denervation in the one-kidney, one clip hypertensive rat model significantly reduces blood pressure and normalizes hypothalamic norepinephrine content, highlighting the role of renal nerves in central sympathetic regulation.
Cite This Study
Winternitz et al. (1982) studied One-kidney one clip hypertension. Renal denervation vs. Sham operation was evaluated on Systolic blood pressure (p=<0.001). Renal denervation in rats with one-kidney one clip hypertension significantly decreased systolic blood pressure from 189 to 151 mm Hg (p<0.001) and reduced hypothalamic norepinephrine to control levels.