January 1, 1986Journal of Cardiovascular Pharmacology

Vascular Angiotensin Converting Enzyme in the Development of Renal Hypertension

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Population

In vitro helically cut strips of arteries isolated from dogs, and in vivo two-kidney, one-clip hypertensive…

Comparison

Unilateral occlusion of the renal artery and… vs Normotensive rats

Design

Preclinical

Follow-up

16 weeks

Authors

MMMizuo MiyazakiOsaka Medical and Pharmaceutical University TOTomio OkamuraShiga University of Medical Science HOHideki OkunishiShimane University

Discussion

Member takes

Implication

Supports vascular ACE in sustaining chronic hypertension in rats; hypothesis-generating for local RAS targeting, pending human validation.

Structured PICO

Population

In vitro helically cut strips of arteries isolated from dogs, and in vivo two-kidney, one-clip hypertensive rats compared to normotensive rats

Intervention

Unilateral occlusion of the renal artery (two-kidney, one-clip model) and exposure to angiotensin (ANG) I, ACE inhibitor, or ANG II antagonist

Comparator

Normotensive rats

Outcome

Vascular ACE activity, plasma-renin activity (PRA), aortic renin activity, and ANG I to ANG II conversion ratesurrogate

Vascular ACE appears to play an important role in the maintenance of chronic hypertension by locally producing ANG II from ANG I.

Cite This Study

Miyazaki et al. (1986) studied this question.

synapsesocial.com/papers/6a88ecf9d7d368998875fda4 https://doi.org/10.1097/00005344-198600101-00012

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January 1, 1986Journal of Cardiovascular Pharmacology

Vascular Angiotensin Converting Enzyme in the Development of Renal Hypertension

View Full Paper

Ask AI

Bookmark

Population

In vitro helically cut strips of arteries isolated from dogs, and in vivo two-kidney, one-clip hypertensive…

Comparison

Unilateral occlusion of the renal artery and… vs Normotensive rats

Design

Preclinical

Follow-up

16 weeks

Authors

MMMizuo MiyazakiOsaka Medical and Pharmaceutical University TOTomio OkamuraShiga University of Medical Science HOHideki OkunishiShimane University

Discussion

Member takes

Implication

Supports vascular ACE in sustaining chronic hypertension in rats; hypothesis-generating for local RAS targeting, pending human validation.

Structured PICO

Population

In vitro helically cut strips of arteries isolated from dogs, and in vivo two-kidney, one-clip hypertensive rats compared to normotensive rats

Intervention

Unilateral occlusion of the renal artery (two-kidney, one-clip model) and exposure to angiotensin (ANG) I, ACE inhibitor, or ANG II antagonist

Comparator

Normotensive rats

Outcome

Vascular ACE activity, plasma-renin activity (PRA), aortic renin activity, and ANG I to ANG II conversion ratesurrogate

Vascular ACE appears to play an important role in the maintenance of chronic hypertension by locally producing ANG II from ANG I.

Cite This Study

Miyazaki et al. (1986) studied this question.

synapsesocial.com/papers/6a88ecf9d7d368998875fda4 https://doi.org/10.1097/00005344-198600101-00012

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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