Key result
A single oral administration of enalapril in spontaneously hypertensive rats reduced blood pressure, which coincided with the inhibition of renal cortical and aortic ACE, but not plasma ACE.
Population
Spontaneously hypertensive rats, stroke-prone spontaneously hypertensive rats aged 7 to 22 weeks, and…
Design
Preclinical
Follow-up
From 7 to 22 weeks of age (for SHRSP observation)
Authors
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Renal ACE–BP links in animals remain hypothesis-generating; human relevance and causality need prospective confirmation.
Changes in renal cortical ACE activity, which reflects brush-border enzyme activity, are associated with blood pressure regulation in hypertensive rat models.
Ikemoto et al. (1986) studied Hypertension (animal model). Enalapril was evaluated on Blood pressure and ACE activity. A single oral administration of enalapril in spontaneously hypertensive rats reduced blood pressure, which coincided with the inhibition of renal cortical and aortic ACE, but not plasma ACE.
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