Why the study?
Does sodium loading differentially regulate vascular ACE gene expression and activity in stroke-prone spontaneously hypertensive rats compared to normotensive Wistar-Kyoto rats?
Population
Wistar-Kyoto (WKY) rats and stroke-prone spontaneously hypertensive rats (SHRSP) at different ages
Comparison
Sodium loading vs Basal conditions and normotensive WKY rats
Design
Preclinical
Authors
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May inform mechanisms of salt-sensitive hypertension; leaves open clinical relevance pending human studies.
Does sodium loading differentially regulate vascular ACE gene expression and activity in stroke-prone spontaneously hypertensive rats compared to normotensive Wistar-Kyoto rats?
Membrane-bound ACE undergoes differential regulation in vascular tissues of stroke-prone spontaneously hypertensive rats compared with normotensive rats, which may contribute to blood pressure regulation.
Fernández‐Alfonso et al. (1994) studied this question.
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