Key result
Renal ACE activity predominates in the inner cortex, where it increases following captopril administration, and is also increased by tissue oxidation.
Population
Rat kidney models, including spontaneously hypertensive rats
Design
Preclinical
Authors
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Should not yet change ACE inhibitor use in CKD; leaves open whether inner-cortical ACE heterogeneity modulates efficacy or oxidative responses in humans.
This preclinical study demonstrates that renal ACE is concentrated in the inner cortex and its activity is upregulated by ACE inhibition and tissue oxidation.
Ikemoto et al. (2008) studied this question. Captopril and oxidizing agents was evaluated on Renal ACE activity. Renal ACE activity predominates in the inner cortex, where it increases following captopril administration, and is also increased by tissue oxidation.
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