Population
Rat aorta (two-kidney, one-clip hypertensive rats and sham-operated rats)
Comparison
Renovascular hypertension vs Sham-operated rats
Design
Preclinical
Follow-up
15 days, 1 and 3 months
Authors
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Local ACE upregulation in rat aorta extends tissue RAS evidence; leaves open human renovascular hypertension relevance.
ACE gene expression occurs in the smooth muscle of rat aorta and is upregulated in renovascular hypertension.
Arnal et al. (1994) studied this question.
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