Key result
Aortic angiotensin-converting enzyme activity was significantly higher in 1-clip, 2-kidney Goldblatt hypertensive rats compared to normotensive controls (6.9 vs 4.1 U, p<0.05).
Population
Normotensive and experimental hypertensive rats
Comparison
Induction of experimental hypertension vs Normotensive rats
Design
Preclinical
Authors
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No clinical implications; hypothesis-generating for vascular ACE in renovascular hypertension.
Absolute Event Rate: 6.9% vs 4.1%
p-value: p=<0.05
Increased angiotensin-converting enzyme activity in arterial tissue may contribute to the initiation or development of 1-clip, 2-kidney Goldblatt hypertension in rats.
Mizuno et al. (1982) studied Experimental hypertension (n=42). 1-clip, 2-kidney Goldblatt experimental hypertension vs. Normotensive control was evaluated on Angiotensin-converting enzyme activity in aortic homogenate (U) (p=<0.05). Aortic angiotensin-converting enzyme activity was significantly higher in 1-clip, 2-kidney Goldblatt hypertensive rats compared to normotensive controls (6.9 vs 4.1 U, p<0.05).
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