Why the study?
Do ACE inhibitors Enalapril and SA446 lower blood pressure and inhibit renal cortical ACE in hypertensive rats?
Population
Hypertensive rats (SHR and SHRSP) and Wistar Kyoto rats
Design
Preclinical
Authors
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May implicate tissue ACE inhibition in BP lowering in rats; leaves open relevance to human hypertension.
Do ACE inhibitors Enalapril and SA446 lower blood pressure and inhibit renal cortical ACE in hypertensive rats?
Renal cortical ACE activity, particularly in the brush border membrane, appears to play a significant role in blood pressure regulation and hypertension development in rat models.
Ikemoto et al. (1987) studied this question.
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