Why the study?
Does intravenous infusion of Sar1-Thr8-angiotensin II reduce arterial pressure in the acute and chronic phases of two-kidney hypertension in dogs?
Population
9 conscious, trained dogs with a new model of two-kidney hypertension produced by partial constriction…
Comparison
Intravenous infusion of an angiotensin II… vs Baseline/control state
Design
Preclinical
Follow-up
3 weeks after complete occlusion
Authors
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Suggests phase-specific RAS role in canine renal hypertension; leaves open relevance to human chronic hypertension.
Does intravenous infusion of Sar1-Thr8-angiotensin II reduce arterial pressure in the acute and chronic phases of two-kidney hypertension in dogs?
The renin-angiotensin system does not appear to be directly involved in the chronic phase of two-kidney hypertension in this dog model.
Masaki et al. (1977) studied this question.
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